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KMID : 1123920070210051271
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 5 p.1271 ~ p.1277
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Mechanism of Sagunja-tang Extract and Zingiberis rhizoma recens Juice on the Cerebral Hemodynamics in Normal Rats
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Kim Geo-Woong
Jung Hyun-Woo
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Abstract
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This study was designed to investigate the effects of Sagunja-tang Extract & Zingiberis rhizoma recens Juice (SEZJ) and Zingiberis rhizoma recens Juice (ZRJ) on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. The results were as follows ; SEZJ and ZRJ significantly increased rCBF in a dose-dependent manner, while it did not change MABP. This results suggest that SEZJ and ZRJ significantly increased rCBF by dilating pial arterial diameter. Increase of SEZJ-induced rCBF was significantly inhibited by pretreatment with methylene blue (10 , i.p.), an inhibitor of guanylate cyclase, and indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. SEZJ-induced MABP was significantly increased by pretreatment with indomethacin but was not changed by methylene blue. These results suggested that the action of SEZJ was mediated by cyclic 3’,5’-guanosine monophosphate.
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KEYWORD
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Sagunja-tang Extract, Zingiberis rhizoma recens Juice, regional cerebral blood flow, mean arterial blood pressure, indomethacin, methylene blue
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